Soreness and nandrolone decanoate tension of the mammary glands, breast enlargement, discharge from the breast; spotting and breakthrough uterine bleeding; headache; migraine; changes in libido; reduction / mood changes;poor tolerance of contact lenses; blurred vision; nausea; vomiting; stomach ache; changes in vaginal secretion; skin rash; erythema nodosum; erythema multiforme; generalized itching; cholestatic jaundice;fluid retention; change in body weight; allergic reactions. Rarely – increased fatigue, diarrhea. Sometimes it can develop chloasma, especially in women with a history of chloasma during pregnancy.
How and when taking other combined oral contraceptives in rare cases may develop thrombosis and thromboembolism.
Symptoms that may occur in overdose:. Nausea, vomiting, spotting or metrorrhagia
no specific antidote, symptomatic treatment should be conducted.
Interaction with other drugs
sulfonamides, pyrazolone derivatives can enhance the metabolism of a part of the preparation of steroid hormones.
Long-term treatment with drugs that induce liver enzymes, resulting in increased clearance of sex hormones can lead to breakthrough bleeding and / or a reduction in contraceptive effectiveness Trikvilar drug.
It such drugs include phenytoin, barbiturates, primidone, carbamazepine and rifampicin; also there are suggestions with regard to oxcarbazepine, topiramate, felbamate, ritonavir and griseofulvin and products containing St. John’s wort.
The contraceptive protection is reduced when taking antibiotics (such as ampicillin and tetracyclines), since, according to some sources, some antibiotics may reduce intrahepatic circulation of estrogen, the thus, lowering the concentration of ethinyl estradiol.
Oral contraceptives combined can influence the metabolism of other drugs (including cyclosporine), which leads to a change in their concentration in the plasma and tissues.
During reception of antibiotics (such as ampicillin and tetracycline) and for 7 days after their withdrawal should additionally use a barrier method of contraception.
If the period of use of barrier methods of protection ends later than Bean in a package, you need to go to the next package trikvilar without the usual free interval pills.
If any of the conditions / risk factors mentioned nandrolone decanoate below are currently available, you should carefully weigh the potential risks and expected benefits of treatment Trikvilar in each individual case and discussed with the woman before she decides to start taking the drug. In the event of aggravation, the gain or the first manifestation of any of these conditions or risk factors, the woman should consult with your doctor, who can decide whether to cancel the drug. Diseases of the cardiovascular system was found a slight increase in the incidence of venous and arterial thrombosis and thromboembolism at reception of combined oral contraceptives. Approximate frequency of venous thromboembolism (deep vein thrombosis or pulmonary embolism) in women taking oral contraceptives with low estrogen dose (less than 50 micrograms ethinylestradiol) is up to 4 per 10 000 women per year, compared with 0.5 -3 per 10 000 women per year in women . However, the incidence of venous thromboembolism , developing while taking combined oral contraceptives, is less than the rate associated with pregnancy (6 per 10 000 pregnant women per year). In women taking combined oral contraceptives are described in extremely rare cases, thrombosis of other blood vessels, for example, hepatic, mesenteric, renal arteries and veins, retinal vein and its branches. .
Communication with the reception of combined oral contraceptives has not been proved Women need to stop taking the drug and consult a doctor if you develop symptoms of venous or arterial thrombosis or cerebrovascular disorders, which can include: unilateral leg pain and / or swelling; sudden severe pain in the chest, with or without irradiation in the left arm; sudden shortness of breath; sudden attack of coughing; any unusual, severe, prolonged headache; sudden partial or complete loss of vision; diplopia; slurred speech or aphasia; dizziness; loss of consciousness and / or without convulsive seizure; weakness or very marked numbness suddenly appeared on one side or in one part of the body; motor disturbances; symptoms of “acute abdomen”.
The risk of thrombosis (venous and / or arterial) and thromboembolism is increased: – age – smokers (with the number of cigarettes or increasing age the risk further increases, especially in women older than 35 years), in the presence of: – family history (ie . venous or arterial thromboembolism ever in close relatives or parents at a relatively young age); if the supposed hereditary predisposition, the woman should be assessed and the appropriate specialist to solve the question of the possibility ; – dislipoproteinemia; – hypertension; – migraine, – disease of the heart valves ; – atrial fibrillation; – prolonged immobilization, major surgery, any surgery to the legs, or major trauma. In the case of the planned operation should stop taking the drug for at nandrolone decanoate least 4-6 weeks before it and not to renew the appointment within 2 weeks after the immobilization. It is necessary to take into account the increased risk of thromboembolism during the postpartum period.