deca durabolin cycle

Sodium concentration is normalized with the cancellation (dose reduction) deca durabolin cycleor conservative treatment (restriction of fluid intake). Patients with impaired renal function, and low concentration of sodium in the blood serum, or in patients receiving concomitant treatment with drugs that promote sodium excretion from the body (diuretics, drugs affecting the secretion of antidiuretic hormone) before therapy  should determine the concentration of sodium in the serum. Further should be controlled in the serum sodium concentration of 2 weeks after initiation of therapy and then monthly for 3 months or as needed. With special attention to these risk factors should be treated in older patients. The appointment of diuretics and other drugs that reduce the concentration of sodium in the blood serum of patients treated  should follow the same recommendations. When the appearance of clinical symptoms of hyponatremia, measure the sodium concentration in the blood serum. For the remaining patients, the measurement of the concentration of sodium in the blood serum can be carried out during routine blood tests.
In the treatment of patients  in very rare cases, it noted the development of agranulocytosis, aplastic anemia and pancytopenia. Considering the small frequency of occurrence of agranulocytosis, aplastic anemia and pancytopenia, the presence of confounding factors (eg, concomitant use of other drugs, comorbidities), a causal relationship between the development of adverse events data and the use of the drug can not be established. With the development of symptom suppression of bone marrow hematopoiesis is necessary to consider the abolition of the drug.
Patients treated with anticonvulsants, rarely observed episodes of suicidal behavior and thinking. The results of meta-randomized placebo-controlled studies have shown a small increased risk of suicidal behavior in patients treated with anticonvulsants. The mechanism of increase suicide risk in these patients is not established. Stages of treatment requires careful monitoring of patients receiving drug treatment.
It is necessary to carry out the control of body weight in all patients with heart failure to timely identification of fluid retention. When liquid or delay in the progression of heart failure symptoms sodium concentration should be determined in the blood serum. In case of hyponatremia should limit the amount of fluid consumed. Since the use of oxcarbazepine in very rare cases may impair cardiac conduction, the need for careful monitoring of patients with prior conduction disturbances , receiving deca durabolin cycle. When using  rarely reported on the development of severe dermatological reactions, such syndrome, toxic epidermal necrolysis (Lyell’s syndrome), exudative erythema multiforme. Patients with the above dermatological reactions may require hospitalization in connection with the development of life-threatening conditions; very rarely can be fatal. When applying  dermatological reactions were observed in both children and adults, and developed an average of 19 days after the start of dosing. There are some reports of recurrence of skin reactions at the resumption of receiving . With the development of skin reactions during treatment  should consider the abolition of the drug and the appointment of other antiepileptic drugs.
There have been reports of rare cases of hepatitis, which in most cases were resolved successfully. At suspicion on a hepatitis need to consider the abolition of the drug.
Women of childbearing age taking oral contraceptives at the same time  should be warned about the possible decrease in the effectiveness of hormonal contraceptives. This category of patients receiving  is recommended additional use non-hormonal methods of contraception.
Women of childbearing age  recommended, if possible, as monotherapy.
As with any antiepileptic drugs, deca durabolin cycle should be withdrawn gradually because of the risk of increased frequency of seizures.
Trileptal in form for oral suspension contains ethanol in an amount of less than 100 mg per dose. The slurry also contains the parabens, which can cause allergic reactions (possibly delayed).
The structure of the suspension for oral administration include sorbitol, therefore Trileptal in the form of suspensions should not be administered to patients with the inherited disorder of tolerance to fructose.

The effect on the ability to drive vehicles and use machines Patients who during treatment with deca durabolin cyclearises dizziness, drowsiness or other disorders of the central nervous system, do not drive vehicles or operate machinery during treatment.





There are few reports of overdose. The maximum dose described in the reports was approximately g. After the symptomatic treatment of all cases achieved recovery. Symptoms: drowsiness, dizziness, nausea, vomiting, hyperkinesia, hyponatraemia, ataxia, nystagmus.
Treatment. There is no specific antidote. Symptomatic and supportive treatment. It should be borne in mind that in order to reduce absorption of oxcarbazepine may be conducted gastric lavage and an appointment activated carbon.

Interaction with other medicinal products and other forms of interaction . The inhibition of enzymes oxcarbazepine and its pharmacologically active metabolite are inhibitors of cytochrome . Thus, the simultaneous use Trileptal in high doses and drugs are metabolized with nandrolone (eg, phenobarbital, phenytoin), can lead to their interaction. Some patients may require a dose reduction  substrates. It has been demonstrated that oxcarbazepine s weak or does not interact with the following microsomal enzymes. The induction of enzymes As inducers of cytochrome , oxcarbazepine  reduce plasma concentrations of drugs metabolized by these enzymes: digidropiridinovgh calcium antagonists, oral contraceptives, and antiepileptic drugs (eg, carbamazepine). In an application with Trileptalom also may reduce plasma concentrations of other drugs that are substrates for enzymes , (eg, drugs of immunosuppressants – cyclosporine). Since in vitro  is a weak inducer transferase, it is unlikely that in vivo it is able to affect the metabolism of drugs that are excreted as conjugates with glyukurokovoy acid (eg, valproic acid and lamotrigine). However, even taking into account the weak inducing ability of oxcarbazepine , may require increased doses of both of the drugs that are metabolized  transferase. In case of cancellation  may require dose reduction of these drugs. With In vitro, studies have confirmed the ability of inducing a weak oxcarbazepine and nandrolone with regard to isozymes of subsystems nzymes. Inducing influence of oxcarbazepine  to other enzymes known.

  • The concentration of phenytoin in blood plasma increases to 40% while applying Trileptal a dose of 1200 mg daily or higher. Therefore, when using Trileptal in the above doses may need to reduce the dose of phenytoin.
    Increasing the concentration of phenobarbital in serum while the use slightly (15%) With the simultaneous use of strong inducers  (ie carbamazepine, phenytoin and phenobarbital) decreases the concentration.
    have Trileptal showed no auto-induction phenomena. Hormonal contraceptives proved  interaction with the components of oral contraceptives: ethinyl estradiol and levonorgestrel. Mean  values for them is reduced by 48-52% and 32-52%, respectively.  Interaction studies with other oral or implanted contraceptives have been conducted. Thus, the simultaneous use nandrolone and hormonal contraceptives can lead to reduced efficiency of the latter. Calcium channel blockers simultaneous use  and felodipine may reduce the value  of felodipine at 28%, although the plasma concentration remains within the therapeutic range. On the other hand, while the use of verapamil  may decrease in serum concentration of 20%. This reduction in the concentration  in the serum has clinical importance. Interaction with other drugs cimetidine, erythromycin, dextropropoxyphene not affect the pharmacokinetic parameters ; viloksazin little effect on the plasma concentration . There was no any interaction with warfarin as coadministration with single and repeated.

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deca 200

Before taking oral deca 200 suspension Shake well and immediately measure out the required amount of suspension. The required dose (ml) are drawn from the bottle using the supplied syringe. When using a 10 ml syringe (provided with a 250 ml bottle – for adults and older children) amount of the slurry should be rounded up to 0.5 ml. When using a 1 ml syringe (provided with the bottle of 100 ml – for younger children), the number of suspensions should be rounded up to 0.1 ml. After each use, should be tightly closed vial and wipe the gun with a clean dry cloth. The suspension can be taken directly from the syringe or diluted with a little water before taking. Open the vial to store no more than 7 weeks.
Oral suspension and film-coated tablets are used interchangeably at equivalent doses.

Side effects
most frequently reported the following adverse reactions:. Drowsiness, headache, dizziness, diplopia, nausea, vomiting, fatigue (more than 10% of patients)
In clinical studies it was shown that adverse effects are usually mild or moderately expressed, . are transient and occur mainly at the beginning of therapy
The following data summarize the information about adverse events reported in clinical trials, as well as data on the safety profile of the drug obtained in the course of its use in clinical practice.
Criteria for assessing the incidence of adverse events: . From the hematopoietic system: sometimes – leukopenia; very rarely – the suppression of bone marrow hematopoiesis, agranulocytosis, aplastic anemia, neutropenia, pancytopenia, thrombocytopenia. Immune system: very rarely – hypersensitivity accompanied by fever and rash (including multiple organ disorders).

With the development of hypersensitivity reactions may result in circulatory and lymphatic systems (eosinophilia, thrombocytopenia, lymphadenopathy, splenomegaly), muscles and joints (myalgia, swelling in the joints, arthralgia), nervous system (encephalopathy), kidney (proteinuria, interstitial nephritis, renal failure ), pulmonary deca 200 (dyspnea, pulmonary edema, bronchospasm, interstitial inflammation), abnormal liver function, angioedema, anaphylactic reactions. Metabolic and nutrition disorders: often – hyponatremia; very rarely – hyponatremia, leading to the development of signs and symptoms, such as seizures, confusion, decreased level of consciousness, encephalopathy, visual disturbances (including “blurred” vision), nausea, vomiting, folic acid deficiency; very rarely – hypothyroidism. On the part of the central nervous system: very often – drowsiness, headache, dizziness; often – ataxia, tremor, nystagmus, disturbance of attention, amnesia; confusion, depression, apathy, agitation, emotional lability. From the senses : very often – diplopia;often – visual impairment, “blurred” vision, vertigo.

On the part of the cardiovascular system: very rarely – arrhythmias,  hypertension. On the part of the gastrointestinal tract: often – nausea, vomiting; often – diarrhea, constipation, stomach pain; very rarely – pancreatitis and / or an increase in lipase and / or amylase. Liver and zhepchevyvodyaschih ways: very rarely – hepatitis. Dermatological reactions: often – a rash, alopecia, acne; sometimes – urticaria; very rarely – angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome), erythema multiforme. On the part of the connective tissue: very rare deca 200 – systemic lupus erythematosus. Other: very often – feeling tired; often – asthenia. Disorders laboratory parameters: sometimes – increased activity of liver enzymes, increased concentration of alkaline phosphatase in the blood. In very rare cases during treatment with Trileptal may develop clinically significant hyponatremia . With a frequency of> 1% – <10% (often) had ataxia, irritability, vomiting, lethargy, fatigue, nystagmus, tremor, decreased appetite, increase in the concentration of uric acid in the blood.

deca side effects

Can be used both as a monotherapy and in combination with other antiepileptic medications. In both cases, treatment  begin with a clinically deca side effects effective dose, number of intakes – 2 times a day. The dose may be increased depending on the response to therapy. When replacing another antiepileptic  in the reception at the beginning  should gradually reduce the dose of the drug being replaced. When using deca side effects as part of combination therapy may require dose reduction of concomitant antiepileptic drugs, and / or a slower increase in .  Can be taken without regard to food intake (during, after a meal or between meals).
The following recommendations are patients with normal renal function.
there is no need to control the concentration of active substance in plasma with the purpose of optimizing  therapy for these patients.
in tablets there are risks, they can be broken into two parts for ease of swallowing.
When using in children under 3 years who can not swallow tablets and, in cases where it is impossible to measure the required dose of the drug when used in the form of tablets, l administered in the form of a suspension for oral administration.

Adults and older patients Monotherapy initial dose is 600 mg per day (8.10 mg / kg body weight per day), divided into 2 doses. Good therapeutic response is observed in the dose range of 600-2400 mg per day. If necessary, you can gradually increase the dose. The dose is increased by no more than 600 mg / day with an interval of about one week, to achieve the desired therapeutic response. In stationary conditions have experience rapid increasing doses up to 2400 mg per day for 48 hours.

The combination therapy . The starting dose is 600 mg deca side effectsday (8-10 mg / kg body weight per day), divided into 2 doses. Good therapeutic response is observed in the dose range of 600-2400 mg per day. If necessary, you can gradually increase the dose. The dose is increased by no more than 600 mg / day with an interval of about one week to achieve the desired therapeutic response. The use of a daily above 2,400mg not studied. There is limited experience with the use l in a daily dose of 4,200 mg. Ad hoc correction dosing regimen for elderly patients is not required, since the therapeutic dose set individually. Children  monotherapy and when using the drug in combination therapy recommended initial dose – 8-10 mg / kg of body weight per day divided into 2 doses. If necessary to achieve the desired therapeutic effect, possibly a gradual increase in the dose – at intervals of about 1 week dose increased – up to 10 mg / kg / day, up to a maximum daily dose rate of 60 mg / kg body weight. in applying l as monotherapy and in combination therapy, for adjusting the apparent weight of the body clearance in children is significantly reduced with increasing age. Children aged 1 month to 4 years of age may require dose, 2 times the dose for adults, when adjusting for body weight; children aged 4 to 12 years old may need a dose in excess of 50% dose for adults, when adjusting for body weight. In children between the ages of 1 month to 4 years, the influence of antiepileptic drugs – inducers of liver enzymes in their apparent clearance is expressed more extent than in children older age groups (when adjusting for body weight).

When using Trileptal in children aged 1 month to 4 years, in combination with antiepileptic drugs – inducers of liver enzymes may need a dose of oxcarbazepine by 60% higher (when adjusting for body weight) than with monotherapy Trileptalom or when used in combination with the antiepileptic means not inducing enzymes. For children older age groups during combination therapy deca side effects with inducers of liver enzymes may need a slight increase in the dose of the drug compared with monotherapy. In children younger than three years, the drug should be used in the form of syrup because of the difficulties of application of solid dosage forms in this age group. patients with impaired liver function is not required correction dosing regimen in patients with mild to moderate hepatic impairment. patients with impaired renal function For patients with impaired renal function (creatinine clearance less than 30 ml / min) the recommended starting dose is 300 mg / day; dose should increase slowly until the desired therapeutic response. Instructions for oral suspension: Conversion Table Trileptal dose of mg per ml.