When using Trileptal in clinical practice in some cases (postmarketing reports) noted the development of immediate hypersensitivity type (I type), including rash, pruritus, urticaria, angioneurotic edema and anaphylactic reactions. Angioedema and anaphylactic reactions with the defeat of the larynx, vocal folds (glottis region), lips, eyelids developed as in the first and in readmission Trileptal. In deca steroids case of hypersensitivity köpa testogel of immediate type Trileptap should be lifted immediately appoint an alternative therapy.
It should be used with caution to patients with known hypersensitivity to carbamazepine, since this group of patients in approximately 25-30% of cases may develop hypersensitivity reactions to oxcarbazepine. In patients without a history of indications hypersensitivity to carbamazepine, also may develop hypersensitivity reactions to the drug, including multiple organ disorders.
The use for patients with severe hepatic impairment has not been studied so caution should be used drug in these patients.
The use of pregnancy and lactation Experience with during pregnancy is limited. Available reports indicate a possible connection of the drug during pregnancy with the development of birth defects (such as cleft palate). In experimental studies, the application l in toxic doses showed an increase in fetal mortality, retardation and impaired development and fetal growth. If the patient becomes pregnant or plans to become pregnant while using the drug, as well as in the event of the issue of the appointment during pregnancy need to carefully compare the expected benefits of therapy and the possible risks to the fetus, especially in the I trimester of pregnancy.
- If pregnancy should use the minimum effective dose.
- When sufficient clinical efficacy for women of child-bearing period, Trileptal should be administered as a monotherapy.
- The patient must be advised of the possible violations of fetal development and the need for antenatal diagnosis.
- During pregnancy should not interrupt deca steroids an effective antiepileptic treatment, because the progression of the disease can have a negative impact on the mother and the fetus.
It is known that during pregnancy develop folic acid deficiency. Antiepileptic drugs can enhance the deficit, which is one of the possible causes of violations of fetal development, so it is recommended additional intake of folic acid.
Using the drug during pregnancy should take into account that the physiological changes that occur in the body of a pregnant patient may lead to a gradual reduction in the level of 10 -monogidroksiproizvodnogo oxcarbazepine in the blood plasma. For maximum control köpa anabola steroider i sverige of the symptoms of the disease in pregnant patients the clinical effect of the drug is necessary to regularly assess and define concentration in blood plasma. Determination recommended plasma levels also carry out during the postpartum period, especially if during pregnancy increased dose of the drug. There are reports that the use of antiepileptic drugs during pregnancy can lead to increased bleeding in newborns. As a precaution, it is recommended the appointment in the last few weeks of pregnancy, and newborns who receive Trileptal mother. Oxcarbazepine cross the placental barrier.
Oxcarbazepine are excreted in breast milk. The ratio of the concentration in milk and plasma was 0.5 for both substances. Since the impact on newborns oxcarbazepine received breast milk deca steroids is unknown, Trileptal should not be used during breastfeeding.
- Use in children under the age of 1 month . Use of the drug in children under the age of 1 month in controlled clinical trials has not been studied.