Can be used both as a monotherapy and in combination with other antiepileptic medications. In both cases, treatment begin with a clinically deca side effects effective dose, number of intakes – 2 times a day. The dose may be increased depending on the response to therapy. When replacing another antiepileptic in the reception at the beginning should gradually reduce the dose of the drug being replaced. When using deca side effects as part of combination therapy may require dose reduction of concomitant antiepileptic drugs, and / or a slower increase in . Can be taken without regard to food intake (during, after a meal or between meals).
The following recommendations are patients with normal renal function.
there is no need to control the concentration of active substance in plasma with the purpose of optimizing therapy for these patients.
in tablets there are risks, they can be broken into two parts for ease of swallowing.
When using in children under 3 years who can not swallow tablets and, in cases where it is impossible to measure the required dose of the drug when used in the form of tablets, l administered in the form of a suspension for oral administration.
Adults and older patients Monotherapy initial dose is 600 mg per day (8.10 mg / kg body weight per day), divided into 2 doses. Good therapeutic response is observed in the dose range of 600-2400 mg per day. If necessary, you can gradually increase the dose. The dose is increased by no more than 600 mg / day with an interval of about one week, to achieve the desired therapeutic response. In stationary conditions have experience rapid increasing doses up to 2400 mg per day for 48 hours.
The combination therapy . The starting dose is 600 mg deca side effectsday (8-10 mg / kg body weight per day), divided into 2 doses. Good therapeutic response is observed in the dose range of 600-2400 mg per day. If necessary, you can gradually increase the dose. The dose is increased by no more than 600 mg / day with an interval of about one week to achieve the desired therapeutic response. The use of a daily above 2,400mg not studied. There is limited experience with the use l in a daily dose of 4,200 mg. Ad hoc correction dosing regimen for elderly patients is not required, since the therapeutic dose set individually. Children monotherapy and when using the drug in combination therapy recommended initial dose – 8-10 mg / kg of body weight per day divided into 2 doses. If necessary to achieve the desired therapeutic effect, possibly a gradual increase in the dose – at intervals of about 1 week dose increased – up to 10 mg / kg / day, up to a maximum daily dose rate of 60 mg / kg body weight. in applying l as monotherapy and in combination therapy, for adjusting the apparent weight of the body clearance in children is significantly reduced with increasing age. Children aged 1 month to 4 years of age may require dose, 2 times the dose for adults, when adjusting for body weight; children aged 4 to 12 years old may need a dose in excess of 50% dose for adults, when adjusting for body weight. In children between the ages of 1 month to 4 years, the influence of antiepileptic drugs – inducers of liver enzymes in their apparent clearance is expressed more extent than in children older age groups (when adjusting for body weight).
When using Trileptal in children aged 1 month to 4 years, in combination with antiepileptic drugs – inducers of liver enzymes may need a dose of oxcarbazepine by 60% higher (when adjusting for body weight) than with monotherapy Trileptalom or when used in combination with the antiepileptic means not inducing enzymes. For children older age groups during combination therapy deca side effects with inducers of liver enzymes may need a slight increase in the dose of the drug compared with monotherapy. In children younger than three years, the drug should be used in the form of syrup because of the difficulties of application of solid dosage forms in this age group. patients with impaired liver function is not required correction dosing regimen in patients with mild to moderate hepatic impairment. patients with impaired renal function For patients with impaired renal function (creatinine clearance less than 30 ml / min) the recommended starting dose is 300 mg / day; dose should increase slowly until the desired therapeutic response. Instructions for oral suspension: Conversion Table Trileptal dose of mg per ml.