After oral administration trimetazidnn durabolin rapidly and almost completely absorbed in the gastrointestinal tract. Bioavailability – 90%. The time to reach maximum plasma concentration – 2 chasa (maximum concentration after a single dose of 20 mg of trimetazidine about 55 ng / ml). Easily penetrates the blood-tissue barriers. Poluvyvёdeniya period . Contact with blood plasma proteins – 16%. Report from the body by the kidneys (60% unchanged).

Indications for use
Ischemic heart disease: prevention of angina attacks durabolin (in the complex therapy).

Kohleovestibulyarny violations ischemic nature, such as dizziness, tinnitus, hearing loss. Chorioretinal vascular disorders.


  • Hypersensitivity to any component of the drug;
  • Renal impairment durabolin;
  • Severe hepatic dysfunction;
  • Pregnancy;
  • Lactation;
  • Age 18 years (effectiveness and safety have been established);
  • Rare hereditary disease: lactose intolerance, lactase deficiency, glucose-galactose malabsorption.

Pregnancy and lactation
The drug is contraindicated in pregnancy because durabolin of the lack of clinical data on the safety of its use. If necessary, the appointment during lactation should stop breastfeeding. It is not known whether trimetazidine is excreted in breast milk. In experimental studies found no teratogenic effects of trimetazidine.

Dosing and Administration
Inside, during a meal.
The recommended dosing regimen – 2-3 capsules (40-60 mg) per day, 2-3 hours. The course of treatment – on doctor’s advice.

Side effects:
Allergic reactions (itchy skin), seldom durabolin – dyspeptic symptoms (nausea, vomiting, gastralgia). Rarely – headache, a feeling of palpitations.

Currently, the cases of overdose have been reported.

Interaction with other medicinal products
are not described.

Do not use for the relief of angina attacks. Do not indicated for the initial course of therapy of unstable angina or myocardial infarction.
In the case of angina attack should review and adapt the treatment.

Effect on management of vehicles and mechanisms
Trimetazidine does not affect the ability to drive and transport works and require high speed of psychomotor reactions.