Following oral administration trimebutine is rapidly absorbed from the gastrointestinal tract, maximum plasma concentration decanoate is achieved in 1-2 hours. The bioavailability is 4-6%. The volume of distribution (Vd) – 88 l. The degree of binding to plasma proteins is low – about 5%. Trimebutin slightly crosses the placental barrier.

Metabolism and excretion of
trimebutine biotransformed in the liver and excreted in the urine primarily as metabolites (approximately 70% during the first 24 hours).


  • Motor disorders in functional gastrointestinal disease, gastroesophageal reflux disease, dyspepsia with gastroduodenal disorders (abdominal pain, dyspepsia, nausea, vomiting), irritable bowel syndrome (functional disorder of the gastrointestinal tract, manifested, in particular, pain and abdominal cramps, spasms of the intestine, flatulence, diarrhea and / or constipation).
  • Post-operative paralytic ileus, preparation for radiological and endoscopic examination of the gastrointestinal tract.

Use in children: diarrheal disorders associated with impaired gastrointestinal motility fact.


: Hypersensitivity to the decanoate components included in the composition of the drug. Children under 3 years – for this dosage form.

Application of pregnancy and lactation
is not recommended to use the drug in the I trimester of pregnancy. Do not appoint Trimedat lactation, due to the lack of reliable clinical data supporting the safety of the drug during this period.
In experimental studies revealed no data on the teratogenicity and embryotoxicity drug.

Dosing and Administration
Adults and children from 12 years.: 100-200 mg 3 times a day
Children 3-5 years: 25 mg 3 times daily.
Children 5-12 years: 50 mg 3 times a day .

Side effect
Rare: skin reactions

So far, cases of drug overdose Trimedat were reported.

Interaction with other drugs
drug interactions Trimedat preparation is not described.

Product form
tablets of 100 mg, 200 mg. 10 tablets decanoate in blisters of polyvinyl chloride film and aluminum foil printed patent. At 1, 2 or 3 blisters with instruction on use are placed in a pile of cardboard boxed.

Storage conditions:
The temperature is not above 25 ° C. Keep out of the reach of children.